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Pharmacological inhibition in the ataxia telangiectasia and Rad3-connected protein serine/threonine kinase (ATR; also known as FRAP-related protein (FRP1)) has emerged to be a promising approach for most cancers procedure that exploits synthetic lethal interactions with proteins involved with DNA destruction fix, overcomes resistance to other thera

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a TNF-linked apoptosis inducing ligand; b Multicellular spheroids; c IC50 wasn't identified; d Binding affinity from isothermal calorimetry experiments; e Related inhibition of ULK1 (IC50 or quantitative inhibitory action was not reported).This compound belongs to The category of organic and natural compounds referred to as indolocarbazoles. These

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